Voriconazole and fungal keratitis: a report of two treatment failures

J Ocul Pharmacol Ther. 2006 Dec;22(6):437-9. doi: 10.1089/jop.2006.22.437.

Abstract

Two cases of fungal keratitis, one caused by Fusarium oxysporum and the other by Colletotrichum dematium, that failed treatment with topical voriconazole 1% are presented. These cases are noteworthy in that topical voriconazole was unable to eradicate the corneal infection in both cases, despite relatively low MIC90 tested for each species of 8 and 1 microg/mL, respectively.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Aged, 80 and over
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Colletotrichum / drug effects
  • Colletotrichum / isolation & purification
  • Fusarium / drug effects
  • Fusarium / isolation & purification
  • Humans
  • Keratitis / drug therapy*
  • Keratitis / microbiology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycoses / drug therapy*
  • Mycoses / microbiology
  • Pyrimidines / administration & dosage
  • Pyrimidines / pharmacology
  • Pyrimidines / therapeutic use*
  • Treatment Failure
  • Triazoles / administration & dosage
  • Triazoles / pharmacology
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole