Abstract
[reaction: see text] A stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin has been accomplished via a highly diastereoselective double allylboration reaction of 6-8 and an iodonium ion promoted urethane cyclization for the installation of the C(15) alkoxy function in 3.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alcohols / chemistry
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Allyl Compounds / chemistry
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Boron / chemistry
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Cyclization
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Fibrinolytic Agents / pharmacology*
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Iodine / chemistry
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Ions
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Macrolides / chemical synthesis*
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Models, Chemical
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Stereoisomerism
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Streptomyces / chemistry*
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Urethane / chemistry
Substances
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Alcohols
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Allyl Compounds
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Fibrinolytic Agents
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Ions
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Macrolides
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alkoxyl radical
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tetrafibricin
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Urethane
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Iodine
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Boron