Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line

Akikazu Sakudo; Izuru Nakamura; Deug-Chan Lee; Keiichi Saeki; Kazuyoshi Ikuta; Takashi Onodera

Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line

Protein Pept Lett. 2007;14(1):1-6.

Authors

Akikazu Sakudo¹, Izuru Nakamura, Deug-Chan Lee, Keiichi Saeki, Kazuyoshi Ikuta, Takashi Onodera

Affiliation

¹ Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 17266643

Abstract

The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Death / drug effects
Cell Line
Humans
Hydrophobic and Hydrophilic Interactions*
Neurons / cytology
Neurons / drug effects*
Neurons / metabolism*
Peptide Fragments / chemistry*
Peptide Fragments / toxicity*
Prions / chemistry*
Prions / toxicity*
Superoxide Dismutase

Substances

Peptide Fragments
Prions
Superoxide Dismutase