Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder

Am J Geriatr Psychiatry. 2007 Feb;15(2):174-9. doi: 10.1097/JGP.0b013e31802dd367.

Abstract

Objective: The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder.

Methods: Twenty patients with bipolar disorder (age range: 61-86 years) were administered comprehensive neuropsychologic testing. Structured in-home performance-based assessments of IADLs were performed in 19 of these patients.

Results: Relative to age-equated comparators, bipolar subjects performed worse in information-processing speed and executive functioning. IADL performance was strongly correlated with these cognitive domains.

Conclusions: In euthymic elderly patients with bipolar disorder, decrements in information processing speed and executive functioning characterize cognitive function and are associated with poorer IADL performance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living* / classification
  • Activities of Daily Living* / psychology
  • Aged
  • Aged, 80 and over
  • Anticonvulsants / therapeutic use
  • Antimanic Agents / therapeutic use
  • Bipolar Disorder / diagnosis*
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / psychology
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / psychology
  • Female
  • Humans
  • Lithium Carbonate / therapeutic use
  • Male
  • Middle Aged
  • Neuropsychological Tests / statistics & numerical data
  • Psychometrics / statistics & numerical data
  • Valproic Acid / therapeutic use

Substances

  • Anticonvulsants
  • Antimanic Agents
  • Lithium Carbonate
  • Valproic Acid