Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function

Clin Endocrinol (Oxf). 2007 Mar;66(3):434-9. doi: 10.1111/j.1365-2265.2007.02751.x.

Abstract

Objective: There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregnancy disorders.

Patients and methods: Plasma levels of visfatin and adiponectin were quantified in second-trimester pregnancies with abnormal uterine perfusion and in third-trimester pregnancies with IUGR as compared to healthy controls.

Results: Mean plasma adiponectin levels were significantly increased in women with pathological perfusion (7078 +/- 789 ng/ml) as compared to normal uterine perfusion (4481 +/- 1183 ng/ml) (P < 0.05) whereas visfatin plasma concentrations were not different between these groups. Visfatin levels were significantly elevated in women with IUGR (140.1 +/- 10 ng/ml) as compared to patients with normal outcome (65.5 +/- 11 ng/ml) (P < 0.05). By contrast, adiponectin plasma concentrations were not significantly altered in women with IUGR.

Conclusions: Our data support the view that the adipokines visfatin and adiponectin are differentially regulated in pregnancy complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Analysis of Variance
  • Biomarkers / blood
  • Case-Control Studies
  • Cytokines / blood*
  • Female
  • Fetal Growth Retardation / metabolism*
  • Fetal Growth Retardation / physiopathology
  • Humans
  • Insulin Resistance
  • Nicotinamide Phosphoribosyltransferase
  • Placenta Diseases / metabolism*
  • Placenta Diseases / physiopathology
  • Placental Circulation
  • Pregnancy
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Retrospective Studies

Substances

  • Adiponectin
  • Biomarkers
  • Cytokines
  • Nicotinamide Phosphoribosyltransferase
  • nicotinamide phosphoribosyltransferase, human