Electronic energy delocalization and dissipation in single- and double-stranded DNA

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4794-7. doi: 10.1073/pnas.0606757104. Epub 2007 Mar 12.

Abstract

The mechanism that nature applies to dissipate excess energy from solar UV light absorption in DNA is fundamental, because its efficiency determines the vulnerability of all genetic material to photodamage and subsequent mutations. Using femtosecond time-resolved broadband spectroscopy, we have traced the electronic excitation in both time and space along the base stack in a series of single-stranded and double-stranded DNA oligonucleotides. The obtained results demonstrate not only the presence of delocalized electronic domains (excitons) as a result of UV light absorption, but also reveal the spatial extent of the excitons.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenine
  • DNA, Single-Stranded / metabolism*
  • Electrons*
  • Energy Transfer*
  • Time Factors

Substances

  • DNA, Single-Stranded
  • Adenine