Resolution of Chiari I malformation following acetazolamide therapy

Semin Ophthalmol. 2007 Jan-Mar;22(1):9-11. doi: 10.1080/08820530601162966.

Abstract

A 25-year-old obese woman developed headaches and visual blurring. Examination showed papilledema and cranial MRI showed a large Chiari I malformation. Acetazolamide was initiated and a repeat cranial MRI surprisingly showed resolution of the Chiari I malformation. Chiari I malformation associated with papilledema has never been shown to resolve with acetazolamide therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetazolamide / therapeutic use*
  • Adult
  • Arnold-Chiari Malformation / complications
  • Arnold-Chiari Malformation / diagnosis
  • Arnold-Chiari Malformation / drug therapy*
  • Diuretics / therapeutic use*
  • Female
  • Humans
  • Intracranial Pressure
  • Intraocular Pressure
  • Magnetic Resonance Imaging
  • Papilledema / diagnosis
  • Papilledema / drug therapy
  • Papilledema / etiology

Substances

  • Diuretics
  • Acetazolamide