Abstract
[structure: see text] Two new cyclic peptides, thalassospiramides A and B (1 and 2), were isolated from a new member of the marine alpha-proteobacterium Thalassospira. The thalassospiramides, the structures of which were assigned by combined spectral and chemical methods, bear unusual gamma-amino acids and show immunosuppressive activity in an interleukin-5 production inhibition assay (IC50 = 5 muM for thalassospiramide B).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amination
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Animals
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Hydroxylation
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Immunosuppressive Agents / chemistry*
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Immunosuppressive Agents / metabolism
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Immunosuppressive Agents / pharmacology
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Lymphocytes / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Oceans and Seas
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Pentanoic Acids / chemistry
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Peptides, Cyclic / biosynthesis
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology
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Rhodospirillaceae / chemistry*
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Rhodospirillaceae / metabolism
Substances
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Immunosuppressive Agents
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Pentanoic Acids
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Peptides, Cyclic
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thalassospiramide A
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thalassospiramide B