Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity

Sloan Ayers; Deborah L Zink; Kenneth Mohn; Joanne Staats Powell; Christine M Brown; Terry Murphy; Robert Brand; Seef Pretorius; Dennis Stevenson; Donald Thompson; Sheo B Singh

doi:10.1021/np0604937

Scutiaquinones A and B, perylenequinones from the roots of Scutia myrtina with anthelmintic activity

J Nat Prod. 2007 Mar;70(3):425-7. doi: 10.1021/np0604937.

Authors

Sloan Ayers¹, Deborah L Zink, Kenneth Mohn, Joanne Staats Powell, Christine M Brown, Terry Murphy, Robert Brand, Seef Pretorius, Dennis Stevenson, Donald Thompson, Sheo B Singh

Affiliation

¹ Natural Products Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.

PMID: 17378532
DOI: 10.1021/np0604937

Abstract

Haemonchus contortus is a worm that causes serious infections in livestock. Two new perylenequinones, scutiaquinone A (1) and scutiaquinone B (2), have been isolated from a methanol extract of the roots of Scutia myrtina by bioassay-guided fractionation, using an assay that kills this parasite in vitro. The structures of compounds 1 and 2 were elucidated by analysis of their 1D- and 2D-NMR and MS spectra. The isolation, structure, and anthelmintic activities of compounds 1 and 2 are reported.

MeSH terms

Animals
Animals, Domestic / parasitology*
Anthelmintics* / chemistry
Anthelmintics* / isolation & purification
Anthelmintics* / pharmacology
Haemonchus / drug effects*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Perylene / analogs & derivatives*
Perylene / chemistry
Perylene / isolation & purification
Perylene / pharmacology
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Quinones* / chemistry
Quinones* / isolation & purification
Quinones* / pharmacology
Rhamnaceae / chemistry*
South Africa

Substances

Anthelmintics
Quinones
scutiaquinone A
scutiaquinone B
Perylene