Tumor necrosis factor is critical to control tuberculosis infection

Muazzam Jacobs; Dieudonnée Togbe; Cecile Fremond; Arina Samarina; Nasiema Allie; Tania Botha; Daniela Carlos; Shreemanta K Parida; Sergei Grivennikov; Sergei Nedospasov; Analbery Monteiro; Marc Le Bert; Valerie Quesniaux; Bernhard Ryffel

doi:10.1016/j.micinf.2007.02.002

Tumor necrosis factor is critical to control tuberculosis infection

Microbes Infect. 2007 Apr;9(5):623-8. doi: 10.1016/j.micinf.2007.02.002. Epub 2007 Feb 21.

Authors

Muazzam Jacobs¹, Dieudonnée Togbe, Cecile Fremond, Arina Samarina, Nasiema Allie, Tania Botha, Daniela Carlos, Shreemanta K Parida, Sergei Grivennikov, Sergei Nedospasov, Analbery Monteiro, Marc Le Bert, Valerie Quesniaux, Bernhard Ryffel

Affiliation

¹ Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

PMID: 17409008
DOI: 10.1016/j.micinf.2007.02.002

Abstract

Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Mycobacterium tuberculosis / immunology
Mycobacterium tuberculosis / physiology*
Tuberculosis / immunology*
Tuberculosis / physiopathology
Tumor Necrosis Factors / deficiency
Tumor Necrosis Factors / immunology
Tumor Necrosis Factors / physiology*

Substances

Tumor Necrosis Factors