Abstract
Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Cell Transformation, Neoplastic / genetics*
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Cell Transformation, Neoplastic / metabolism
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Chromosomes, Human, Pair 21 / genetics*
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Chromosomes, Human, Pair 21 / metabolism
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Chromosomes, Human, Pair 8 / genetics*
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Chromosomes, Human, Pair 8 / metabolism
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Core Binding Factor Alpha 2 Subunit / biosynthesis
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Core Binding Factor Alpha 2 Subunit / genetics*
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Humans
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Myeloid, Acute / metabolism
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Leukemia, Myeloid, Acute / pathology
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Mice
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Oncogene Proteins, Fusion / biosynthesis
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Oncogene Proteins, Fusion / genetics*
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RUNX1 Translocation Partner 1 Protein
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Transcription, Genetic
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Translocation, Genetic*
Substances
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AML1-ETO fusion protein, human
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Core Binding Factor Alpha 2 Subunit
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Oncogene Proteins, Fusion
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RUNX1 Translocation Partner 1 Protein