Abstract
We report the case of Mooren's ulcer recurrence after uncomplicated cataract surgery in a 61-year-old woman. This cataract developed because of repetitive inflammation of the anterior chamber and corticotherapy. Local and general corticotherapy with cyclosporin 2% drops was started in association with an anterior lamellar graft and a conjunctival recession due to a preperforation condition. Secondarily cyclophosphamide was necessary to control recurrence with a good anatomic result and an increase in visual acuity. The case updates physiopathologic and diagnostic data on this rare limbic autoimmune ulcerative disease. The diagnosis was made by histology and the dosage of specific autoantibodies against cornea. The prevention of recurrence after surgery requires a long clinical quiescent period, minimally invasive surgery long after inflammation has subsided, and a gradual tapering of corticotherapy over several weeks.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Autoantigens / immunology
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / etiology*
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Autoimmune Diseases / immunology
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Autoimmune Diseases / surgery
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Combined Modality Therapy
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Conjunctiva / surgery
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Conjunctivitis / etiology
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Cornea / immunology
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Corneal Transplantation
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Corneal Ulcer / drug therapy
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Corneal Ulcer / etiology*
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Corneal Ulcer / immunology
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Corneal Ulcer / surgery
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Cyclosporine / therapeutic use
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Female
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Humans
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Immunosuppressive Agents / therapeutic use
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Middle Aged
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Molecular Mimicry
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Neutrophils / immunology
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Phacoemulsification*
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Postoperative Complications / drug therapy
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Postoperative Complications / etiology*
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Postoperative Complications / immunology
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Postoperative Complications / surgery
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Recurrence
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S100 Proteins / immunology
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S100A12 Protein
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Visual Acuity
Substances
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Autoantigens
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Immunosuppressive Agents
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S100 Proteins
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S100A12 Protein
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S100A12 protein, human
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Cyclosporine