Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels

Leukemia. 2007 Jul;21(7):1561-2; author reply 1562-4. doi: 10.1038/sj.leu.2404671. Epub 2007 Apr 12.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
  • Benzamides
  • Drug Resistance, Neoplasm / drug effects
  • Gene Silencing
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Piperazines / pharmacokinetics*
  • Pyrimidines / pharmacokinetics*
  • RNA, Small Interfering / pharmacology*

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Benzamides
  • Piperazines
  • Pyrimidines
  • RNA, Small Interfering
  • Imatinib Mesylate