Clinical importance of HLA-DPB1 in haematopoietic cell transplantation

Tissue Antigens. 2007 Apr:69 Suppl 1:36-41. doi: 10.1111/j.1399-0039.2006.759_4.x.

Abstract

There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Female
  • Graft vs Host Disease / immunology
  • HLA-DP Antigens / genetics
  • HLA-DP Antigens / immunology*
  • HLA-DP beta-Chains
  • Hematologic Neoplasms / immunology
  • Hematologic Neoplasms / therapy*
  • Hematopoietic Stem Cell Transplantation*
  • Histocompatibility Testing / methods*
  • Humans
  • Male
  • Neoplasm Recurrence, Local / etiology
  • Neoplasm Recurrence, Local / therapy
  • Predictive Value of Tests
  • Survival Rate

Substances

  • HLA-DP Antigens
  • HLA-DP beta-Chains
  • HLA-DPB1 antigen