Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes

Antimicrob Agents Chemother. 2007 Aug;51(8):3030-2. doi: 10.1128/AAC.00404-07. Epub 2007 Apr 23.

Abstract

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Antiprotozoal Agents / pharmacology*
  • Cell Line
  • Drug Resistance* / genetics
  • Humans
  • Leishmania / classification
  • Leishmania / drug effects*
  • Leishmania / growth & development*
  • Macrophages / parasitology*
  • Monocytes / parasitology
  • Parasitic Sensitivity Tests
  • Pentamidine / pharmacology*
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism

Substances

  • ATP-Binding Cassette Transporters
  • Antiprotozoal Agents
  • Protozoan Proteins
  • Recombinant Fusion Proteins
  • pentamidine resistance protein 1, Leishmania major
  • Pentamidine