Abstract
Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.
MeSH terms
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Acute Disease
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Animals
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Anti-Bacterial Agents / pharmacology*
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Ciprofloxacin / pharmacology
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Cricetinae
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Doxycycline / pharmacology
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Female
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Fluoroquinolones / pharmacology*
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Gatifloxacin
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Injections, Intraperitoneal
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Leptospira interrogans / classification
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Leptospira interrogans / drug effects*
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Leptospirosis / drug therapy*
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Leptospirosis / mortality
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Levofloxacin
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Mesocricetus
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Ofloxacin / pharmacology
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Serotyping
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Survival Analysis
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Ciprofloxacin
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Levofloxacin
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Ofloxacin
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Gatifloxacin
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Doxycycline