Good news, bad news for missing-self recognition by NK cells: autoimmune control but viral evasion

Immunity. 2007 May;26(5):549-51. doi: 10.1016/j.immuni.2007.05.006.

Abstract

In this issue of Immunity, Voigt et al. (2007) and Lu et al. (2007) extend the understanding of the consequences of missing-self recognition in immune evasion and immune cell regulation via NKRP-1 and CD94-NKG2A inhibitory receptors, respectively.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Surface / immunology
  • Antigens, Surface / metabolism
  • Autoimmunity / immunology*
  • Humans
  • Killer Cells, Natural / immunology*
  • Lectins, C-Type / immunology
  • Lectins, C-Type / metabolism
  • NK Cell Lectin-Like Receptor Subfamily B
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D / immunology
  • NK Cell Lectin-Like Receptor Subfamily D / metabolism
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / metabolism
  • Receptors, Natural Killer Cell
  • Virus Internalization*

Substances

  • Antigens, Surface
  • KLRB1 protein, human
  • KLRC1 protein, human
  • Lectins, C-Type
  • NK Cell Lectin-Like Receptor Subfamily B
  • NK Cell Lectin-Like Receptor Subfamily C
  • NK Cell Lectin-Like Receptor Subfamily D
  • Receptors, Immunologic
  • Receptors, Natural Killer Cell