This study compared the recently introduced cheaper and more accessible wide-range C-reactive protein (wr-CRP) with the commonly used high-sensitivity C-reactive protein (hs-CRP) in patients undergoing coronary angiography. One hundred fifty-two consecutive patients who were admitted to a tertiary medical center and underwent angiography were included in the study. Arterial blood was obtained for the 2 assays at the beginning of angiography. A highly significant correlation (r = 0.983, p <0.001) was found between the 2 methods. This correlation was observed in different clinical scenarios and in different ranges of CRP. In conclusion, the real-time, online, and low-cost wr-CRP assay is a reasonable alternative to the Behring Dade hs-CRP method in the setting of stable and unstable coronary artery disease.