Abstract
Adenosine and 2'-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in gram-positive bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine Nucleotides / chemistry*
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Adenine Nucleotides / pharmacology*
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Bacterial Proteins
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Molecular Structure
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Peptide Synthases
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / enzymology
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Uridine Diphosphate N-Acetylmuramic Acid / analogs & derivatives*
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Uridine Diphosphate N-Acetylmuramic Acid / antagonists & inhibitors
Substances
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Adenine Nucleotides
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Bacterial Proteins
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Uridine Diphosphate N-Acetylmuramic Acid
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muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol
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MurM protein, Streptococcus pneumoniae
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Peptide Synthases