Structural aspects of allorecognition

Curr Opin Immunol. 1991 Oct;3(5):715-21. doi: 10.1016/0952-7915(91)90102-7.

Abstract

The phenomenon of T-cell allorecognition of foreign major histocompatibility molecules has been one of the more enigmatic aspects of T-cell immunology. The molecular basis for allorecognition is unfolding as a result of the application of major histocompatibility complex structure/function analyses in the light of current insights into the three-dimensional structure of major histocompatibility complex products.

Publication types

  • Review

MeSH terms

  • Animals
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Immunity, Cellular*
  • Isoantigens / immunology
  • Major Histocompatibility Complex*
  • Peptide Fragments / immunology
  • Polymorphism, Genetic
  • Protein Conformation
  • Receptors, Antigen, T-Cell / immunology
  • Structure-Activity Relationship
  • T-Lymphocytes / immunology*

Substances

  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Isoantigens
  • Peptide Fragments
  • Receptors, Antigen, T-Cell