Abstract
We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antifungal Agents* / administration & dosage
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Antifungal Agents* / therapeutic use
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Cerebrospinal Fluid / microbiology
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Colony Count, Microbial
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Cryptococcus neoformans / drug effects
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Cryptococcus neoformans / isolation & purification
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Cryptococcus neoformans / pathogenicity
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Disease Models, Animal*
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Fluconazole* / administration & dosage
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Fluconazole* / therapeutic use
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Guinea Pigs
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Humans
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Male
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Meningitis, Cryptococcal* / drug therapy
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Meningitis, Cryptococcal* / microbiology
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Meningitis, Cryptococcal* / physiopathology
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Pyrimidines* / administration & dosage
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Pyrimidines* / therapeutic use
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Triazoles* / administration & dosage
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Triazoles* / therapeutic use
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Voriconazole
Substances
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Antifungal Agents
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Pyrimidines
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Triazoles
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Fluconazole
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Voriconazole