Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex

Bull Exp Biol Med. 2006 Dec;142(6):663-6. doi: 10.1007/s10517-006-0445-0.
[Article in English, Russian]

Abstract

Semax had a pronounced neuroprotective and antiamnesic effect during focal photoinduced ischemia of the prefrontal cortex. Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Adrenocorticotropic Hormone / administration & dosage
  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Adrenocorticotropic Hormone / pharmacology
  • Amnesia / drug therapy*
  • Animals
  • Animals, Outbred Strains
  • Brain Infarction / etiology
  • Brain Infarction / pathology*
  • Brain Infarction / prevention & control*
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / pathology
  • Ischemic Attack, Transient / complications
  • Male
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / pharmacology*
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / pharmacology*
  • Rats
  • Treatment Outcome

Substances

  • Neuroprotective Agents
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone