Abstract
A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.
MeSH terms
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Amyloid Precursor Protein Secretases / antagonists & inhibitors*
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Amyloid beta-Peptides / metabolism
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Animals
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Brain / drug effects
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Brain / metabolism
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Mice
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Mice, Transgenic
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Molecular Structure
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Protein Binding
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Sulfonamides / chemistry*
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Sulfonamides / pharmacology*
Substances
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Amyloid beta-Peptides
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Sulfonamides
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Amyloid Precursor Protein Secretases