A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

Nicole Brendel; Laila P Partida-Martinez; Kirstin Scherlach; Christian Hertweck

doi:10.1039/b707762a

A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

Org Biomol Chem. 2007 Jul 21;5(14):2211-3. doi: 10.1039/b707762a. Epub 2007 Jun 18.

Authors

Nicole Brendel¹, Laila P Partida-Martinez, Kirstin Scherlach, Christian Hertweck

Affiliation

¹ Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, D-07745 Jena, Germany.

PMID: 17609750
DOI: 10.1039/b707762a

Abstract

Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS-NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.

MeSH terms

Antimitotic Agents / chemistry*
Antimitotic Agents / metabolism
Genes, Bacterial*
Genome, Bacterial
Macrolides / chemistry*
Macrolides / metabolism
Models, Biological
Pseudomonas fluorescens / genetics*
Pseudomonas fluorescens / metabolism

Substances

Antimitotic Agents
Macrolides
rhizoxin