Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice

Nat Genet. 2007 Aug;39(8):966-8. doi: 10.1038/ng2065. Epub 2007 Jul 8.

Abstract

The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aneuploidy*
  • Animals
  • Chromosomes, Mammalian / metabolism*
  • Humans
  • Meiosis*
  • Mice
  • Oocytes / cytology*