Synthesis of a triply-bridged molecular gyroscope by a directed meridional cyclization strategy

Org Lett. 2007 Aug 30;9(18):3559-61. doi: 10.1021/ol071379y. Epub 2007 Aug 2.

Abstract

A crystalline triply bridged molecular gyroscope has been prepared and analyzed by single-crystal X-ray diffraction. A convergent synthetic strategy was developed to control the direction of the three bridges, from the preferred two zonal and one meridional arrangement of a one-step cylclization process to the directed three meridional bridges achieved by a north-south desymmetrization.