The transcription profile of the bocavirus bovine parvovirus is unlike those of previously characterized parvoviruses

J Virol. 2007 Nov;81(21):12080-5. doi: 10.1128/JVI.00815-07. Epub 2007 Aug 22.

Abstract

The Bocavirus bovine parvovirus generated a single pre-mRNA from a promoter at its left-hand end; however, the pattern of its alternative polyadenylation and splicing was different from that of other parvoviruses. A large left-hand-end open reading frame (ORF) encoded a nonstructural protein of approximately 95 kDa. An abundant, spliced, internally polyadenylated transcript encoded the viral NP1 protein from an ORF in the center of the genome. Transcripts encoding the capsid proteins were polyadenylated in the right-hand terminal palindrome. This is the first published transcription map of a member of the Bocavirus genus of the Parvovirinae.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Base Sequence
  • Bocavirus / genetics*
  • Cell Line
  • Cloning, Molecular
  • Genome, Viral
  • Humans
  • Models, Genetic
  • Molecular Sequence Data
  • Open Reading Frames
  • Parvovirus / genetics*
  • Protein Structure, Tertiary
  • RNA, Messenger / metabolism
  • Species Specificity
  • Transcription, Genetic*

Substances

  • RNA, Messenger

Associated data

  • GENBANK/DQ335247