Abstract
Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Fungal / administration & dosage*
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Antibodies, Monoclonal / administration & dosage*
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Antigens, Fungal / immunology*
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Cerebrosides / immunology*
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Cryptococcosis / immunology
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Cryptococcosis / mortality
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Cryptococcosis / prevention & control*
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Cryptococcus neoformans / immunology*
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Female
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Mice
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Mice, Inbred A
Substances
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Antibodies, Fungal
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Antibodies, Monoclonal
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Antigens, Fungal
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Cerebrosides
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ceramide monohexoside