Slow progression of human immunodeficiency virus and hepatitis C virus disease in a cohort of coinfected children

Pediatr Infect Dis J. 2007 Sep;26(9):846-9. doi: 10.1097/INF.0b013e318123e8e6.

Abstract

We carried out a retrospective study to determine the evolution of 23 vertically HIV-1/HCV coinfected children and 30 vertically HIV-1 infected children (control group). Six out of 23 HIV-1/HCV coinfected children developed AIDS versus 20 out of 30 HIV-1 children (P < 0.05). HIV-1/HCV children had a good evolution in relation to CD4 and HIV-RNA viral load. They presented higher CD8 counts than HIV-1 children during long periods, and slower progression of HCV liver disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • Child
  • Child, Preschool
  • Cohort Studies
  • Disease Progression
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / virology*
  • HIV*
  • Hepacivirus
  • Hepatitis C / complications
  • Hepatitis C / virology*
  • Humans
  • Infant
  • Male
  • Polymerase Chain Reaction
  • Spain
  • Viral Load