Balancing mucosal immunity: caught between CYLD and Charybdis

Immunity. 2007 Aug;27(2):187-9. doi: 10.1016/j.immuni.2007.08.004.

Abstract

The molecular mechanism of acute lung injury caused by Streptococcus pneumoniae is unclear. In this issue of Immunity, Lim et al. (2007) demonstrate that CYLD, a deubiquinating enzyme, represses the expression of plasminogen activator inhibitor-1, which is critical in preventing tissue damage.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cysteine Endopeptidases / genetics
  • Cysteine Endopeptidases / physiology*
  • Deubiquitinating Enzyme CYLD
  • Immunity, Mucosal
  • Mice
  • Plasminogen Activator Inhibitor 1 / metabolism*
  • Pneumonia, Pneumococcal / enzymology*
  • Pneumonia, Pneumococcal / immunology
  • Respiratory Mucosa / enzymology*
  • Respiratory Mucosa / immunology

Substances

  • Plasminogen Activator Inhibitor 1
  • CYLD protein, mouse
  • Deubiquitinating Enzyme CYLD
  • Cysteine Endopeptidases