Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

Sean T Byrne; Peihua Gu; Jiangbing Zhou; Steven M Denkin; Curtis Chong; David Sullivan; Jun O Liu; Ying Zhang

doi:10.1128/AAC.00753-07

Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

Antimicrob Agents Chemother. 2007 Dec;51(12):4495-7. doi: 10.1128/AAC.00753-07. Epub 2007 Sep 17.

Authors

Sean T Byrne¹, Peihua Gu, Jiangbing Zhou, Steven M Denkin, Curtis Chong, David Sullivan, Jun O Liu, Ying Zhang

Affiliation

¹ Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA.

Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antitubercular Agents / pharmacology
Ditiocarb / pharmacology*
Female
Mice
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / growth & development
Pyrazinamide / pharmacology
Pyrrolidines / pharmacology*
Rifampin / pharmacology
Thiocarbamates / pharmacology*

Substances

Antitubercular Agents
Pyrrolidines
Thiocarbamates
pyrrolidine dithiocarbamic acid
Pyrazinamide
Ditiocarb
Rifampin

Abstract

Publication types

MeSH terms

Substances

Grants and funding