Metabolism and action of 2',2'-difluorodeoxycytidine: self-potentiation of cytotoxicity

Adv Exp Med Biol. 1991:309A:125-30. doi: 10.1007/978-1-4899-2638-8_28.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arabinofuranosylcytosine Triphosphate / pharmacology
  • Base Sequence
  • Cell Line
  • Cell Survival / drug effects
  • DCMP Deaminase / metabolism
  • DNA Polymerase II / metabolism*
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / metabolism
  • Deoxycytidine / pharmacology
  • Deoxycytosine Nucleotides / pharmacology
  • Deoxyribonucleotides / metabolism*
  • Gemcitabine
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides / chemical synthesis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Tumor Stem Cell Assay

Substances

  • Deoxycytosine Nucleotides
  • Deoxyribonucleotides
  • Oligodeoxyribonucleotides
  • Deoxycytidine
  • Arabinofuranosylcytosine Triphosphate
  • 2'-deoxycytidine 5'-triphosphate
  • DNA Polymerase II
  • DCMP Deaminase
  • Gemcitabine