Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA

Angew Chem Int Ed Engl. 2007;46(47):9101-4. doi: 10.1002/anie.200702801.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Molecular Mimicry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptides / chemistry*
  • Peptides / pharmacology*
  • Protein Binding
  • Protein Structure, Secondary
  • RNA / metabolism*
  • X-Ray Diffraction
  • rev Gene Products, Human Immunodeficiency Virus / antagonists & inhibitors*
  • rev Gene Products, Human Immunodeficiency Virus / metabolism

Substances

  • Peptides
  • rev Gene Products, Human Immunodeficiency Virus
  • rev protein, Human Immunodeficiency Virus-1
  • RNA