Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis

Pamaree Billamas; Nat Smittipat; Tada Juthayothin; Arunee Thong-On; Norio Yamada; Hideki Yanai; Prasit Palittapongarnpim

doi:10.1016/j.tube.2007.08.005

Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis

Tuberculosis (Edinb). 2007 Nov;87(6):498-501. doi: 10.1016/j.tube.2007.08.005. Epub 2007 Oct 1.

Authors

Pamaree Billamas¹, Nat Smittipat, Tada Juthayothin, Arunee Thong-On, Norio Yamada, Hideki Yanai, Prasit Palittapongarnpim

Affiliation

¹ National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailand.

PMID: 17910937
DOI: 10.1016/j.tube.2007.08.005

Abstract

The patterns of variable-number tandem repeats (VNTR) genotypes of a clonal group of Mycobacterium tuberculosis Beijing isolates with very similar IS6110-restriction fragment length polymorphism (RFLP) patterns were studied. Differences between VNTR were mostly by a single repeat unit. However, a multiple-unit change also occurred. This suggests that a mechanism other than the slipped-strand mispairing might be responsible for the instability of VNTR in M. tuberculosis as well. This finding is useful for inferring phylogenetics of M. tuberculosis based on the VNTR genotypes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Evolution, Molecular*
Genotype
Humans
Minisatellite Repeats / genetics*
Mycobacterium tuberculosis / classification
Mycobacterium tuberculosis / genetics*
Phylogeny
Polymorphism, Restriction Fragment Length