A second-generation combined linkage physical map of the human genome

Genome Res. 2007 Dec;17(12):1783-6. doi: 10.1101/gr.7156307. Epub 2007 Nov 7.

Abstract

We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, along with confidence intervals, have been estimated for all map intervals. In addition, a regression-based smoothed map is provided that facilitates interpolation of positions of unmapped markers on this map. With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Confidence Intervals
  • Female
  • Genetic Linkage*
  • Genetic Markers
  • Genome, Human*
  • Genotype
  • Humans
  • Male
  • Physical Chromosome Mapping* / methods
  • Physical Chromosome Mapping* / statistics & numerical data
  • Polymorphism, Single Nucleotide

Substances

  • Genetic Markers