Nationwide study of the prevalence, characteristics, and molecular epidemiology of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in France

Antimicrob Agents Chemother. 2008 Feb;52(2):786-9. doi: 10.1128/AAC.00906-07. Epub 2007 Nov 19.

Abstract

Among 10,872 isolates of Enterobacteriaceae from a nationwide study of 88 French hospitals in 2005, 169 (1.7%) expressed an extended-spectrum beta-lactamase. The most prevalent species were Escherichia coli (48.5%), Enterobacter aerogenes (23.7%), and Klebsiella pneumoniae (14.8%). Molecular analysis underlined the polyclonal spread of CTX-M-expressing E. coli, primarily isolates of the CTX-M-1 subgroup.

MeSH terms

  • Enterobacteriaceae / classification
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli / enzymology
  • Escherichia coli / genetics
  • France / epidemiology
  • Microbial Sensitivity Tests
  • Molecular Epidemiology*
  • Prevalence
  • beta-Lactam Resistance
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / classification
  • beta-Lactamases / genetics
  • beta-Lactams

Substances

  • beta-Lactams
  • beta-lactamase TEM-3
  • beta-Lactamases