Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases

J Am Acad Dermatol. 2008 Jan;58(1):142-8. doi: 10.1016/j.jaad.2007.09.023. Epub 2007 Oct 29.

Abstract

Background: Complete surgical excision for lentigo maligna (LM) and LM melanoma (LMM) in the head and neck region may be challenging because of potential significant subclinical extension.

Objective: We sought to review clinical and histologic features of LM and LMM and determine surgical margin necessary for complete excision.

Methods: We conducted a retrospective study of 117 LM and LMM cases treated with a staged margin-controlled excision technique with rush paraffin-embedded sections.

Results: The mean total surgical margin required for excision of LM was 7.1 mm and was 10.3 mm for LMM. Of the tumors diagnosed as LM on initial biopsy specimen, 16% were found to have unsuspected invasion. Total surgical margin was associated with initial clinical lesion diameter.

Limitations: Retrospective and single-institution experience are limitations.

Conclusion: This study corroborates that the standard excision margins for LM and LMM are often inadequate and occult invasive melanoma occurs in LM. An excision technique with permanent sections using a team of dermatopathology and surgery that carefully examines the central tumor and the surgical margins is reliable for the treatment of LM and LMM.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Head and Neck Neoplasms / pathology
  • Head and Neck Neoplasms / surgery*
  • Humans
  • Hutchinson's Melanotic Freckle / pathology
  • Hutchinson's Melanotic Freckle / surgery*
  • Male
  • Melanoma / pathology
  • Melanoma / surgery*
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasms, Multiple Primary / pathology
  • Neoplasms, Multiple Primary / surgery*
  • Retrospective Studies
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery*
  • Surgical Procedures, Operative / methods