Keeping in check painful synapses in central amygdala

Keith Tully; Yan Li; Vadim Y Bolshakov

doi:10.1016/j.neuron.2007.11.011

Keeping in check painful synapses in central amygdala

Neuron. 2007 Dec 6;56(5):757-9. doi: 10.1016/j.neuron.2007.11.011.

Authors

Keith Tully¹, Yan Li, Vadim Y Bolshakov

Affiliation

¹ Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.

PMID: 18054852
DOI: 10.1016/j.neuron.2007.11.011

Abstract

Glutamatergic projections from the parabrachial nucleus to the central amygdala are implicated in pain transmission. In this issue of Neuron, Delaney et al. identify a new form of adrenergic modulation at these synapses, demonstrating that noradrenaline-induced suppression of glutamate release is mediated by a decrease in the number of sites of synaptic transmission without changes in probability of release.

Publication types

Comment

MeSH terms

Adrenergic alpha-Agonists / pharmacology
Amygdala / cytology
Amygdala / physiopathology*
Animals
Emotions / physiology
Glutamic Acid / physiology
Humans
Nerve Fibers / physiology
Neural Pathways / physiology
Neurotransmitter Agents / physiology
Norepinephrine / pharmacology
Pain / physiopathology*
Pain / psychology
Synapses / physiology*
Synaptic Transmission / drug effects

Substances

Adrenergic alpha-Agonists
Neurotransmitter Agents
Glutamic Acid
Norepinephrine