[Rat liver mitochondrial DNA treated with 1,2-dimethylhydrazine]

Vopr Med Khim. 1991 Nov-Dec;37(6):82-4.
[Article in Russian]

Abstract

Primary structure of 5'-end 16S RNA gene of mitochondrial DNA (mDNA) isolated from rat liver tissue within 20 hrs after treatment with 1,2-dimethyl hydrazine, was analyzed. The preparations studied did not contain mutations induced by the drug. The region of mDNA analyzed appears not to be a preferential target for mutagenic effect of 1,2-dimethyl hydrazine unber these experimental conditions.

Publication types

  • English Abstract

MeSH terms

  • 1,2-Dimethylhydrazine
  • Animals
  • Base Sequence
  • Carcinogens / toxicity*
  • DNA, Mitochondrial / drug effects
  • DNA, Mitochondrial / genetics
  • DNA, Mitochondrial / metabolism*
  • Dimethylhydrazines / toxicity*
  • Mitochondria, Liver / drug effects
  • Mitochondria, Liver / metabolism*
  • Molecular Sequence Data
  • RNA, Ribosomal, 16S / genetics
  • Rats

Substances

  • Carcinogens
  • DNA, Mitochondrial
  • Dimethylhydrazines
  • RNA, Ribosomal, 16S
  • 1,2-Dimethylhydrazine