Bi-phenotypic t(9;22)-positive leukemia cell lines from a patient with acute leukemia: NALM-20, established at the onset; and NALM-21, NALM-22 and NALM-23, established after relapse

Hum Cell. 1991 Dec;4(4):335-8.

Abstract

Four leukemia cell lines; NALM-20, established at the onset of leukemia and NALM-21, -22 and -23 established at the relapse of the disease were found to be t(9;22)-positive leukemia lines having the biphenotypic feature of B cell and myeloid cell characteristics. In addition, a polyclonal Epstein-Barr virus-transformed normal B cell line, B250, was established from the peripheral blood at the onset of the disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Surface
  • Blotting, Southern
  • Burkitt Lymphoma / genetics
  • Burkitt Lymphoma / pathology*
  • DNA, Neoplasm / analysis
  • Gene Rearrangement
  • Humans
  • Karyotyping
  • Leukemia, Myeloid / genetics
  • Leukemia, Myeloid / pathology*
  • Male
  • Middle Aged
  • Philadelphia Chromosome
  • Tumor Cells, Cultured

Substances

  • Antigens, Surface
  • DNA, Neoplasm