A kit formulation for preparation of iodine-123-IBZM: a new CNS D-2 dopamine receptor imaging agent

J Nucl Med. 1991 Feb;32(2):339-42.

Abstract

A method for the preparation of iodine-123IBZM, a central nervous system D-2 imaging agent, is reported. By using a rapid filtration technique to remove the unreacted iodide, the preparation can be completed in less than 20 min (overall yield greater than 60%). The product, with high purity (greater than or equal to 95%) and specific activity, is suitable for human use.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Benzamides*
  • Brain / diagnostic imaging*
  • Male
  • Pyrrolidines*
  • Radionuclide Imaging
  • Rats
  • Rats, Inbred Strains
  • Reagent Kits, Diagnostic*
  • Receptors, Dopamine D2
  • Receptors, Dopamine*

Substances

  • Benzamides
  • Pyrrolidines
  • Reagent Kits, Diagnostic
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide