Abstract
A convergent and highly stereocontrolled synthesis of +-superstolide A (1) has been accomplished. Key steps of this synthesis include the intramolecular Suzuki reaction of 26 and the highly diastereoselective transannular Diels-Alder cyclization of macrocyclic octaene 3.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Cyclization
-
Cytotoxins / chemical synthesis*
-
Cytotoxins / chemistry
-
Macrolides / chemical synthesis*
-
Macrolides / chemistry
-
Molecular Conformation
-
Stereoisomerism
-
Tetrahydronaphthalenes / chemical synthesis*
-
Tetrahydronaphthalenes / chemistry
Substances
-
Cytotoxins
-
Macrolides
-
Tetrahydronaphthalenes
-
superstolide A