Abstract
Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved.
MeSH terms
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Animals
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Chickens
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Coccidiosis / drug therapy*
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Coccidiostats / chemical synthesis
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Coccidiostats / pharmacology*
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Cyclic GMP-Dependent Protein Kinases / antagonists & inhibitors
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Eimeria / drug effects*
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Eimeria / enzymology
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Female
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Molecular Structure
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Oocysts / drug effects
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Oocysts / physiology
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Protein Kinase Inhibitors / pharmacology
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / pharmacology*
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Structure-Activity Relationship
Substances
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Coccidiostats
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Protein Kinase Inhibitors
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Pyrroles
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Cyclic GMP-Dependent Protein Kinases