The calcium antagonist PN 200-110 inhibits the reinforcing properties of cocaine

Brain Res Bull. 1991 Mar;26(3):445-7. doi: 10.1016/0361-9230(91)90022-c.

Abstract

The effect of a dihydropyridine (DHP) calcium antagonist, PN 200-110, on cocaine reinforcing properties was investigated using conditioned place preference paradigm. PN 200-110 in nonsedative doses (0.62-1.25-2.5 mg/kg SC) was able to inhibit cocaine-(10 mg/kg IP) induced place preference with ED50 1.57 (0.88-2.58). The results suggest a possible use of DHPs in the treatment of cocaine-related disorders.

MeSH terms

  • Animals
  • Calcium Channel Blockers / pharmacology*
  • Cocaine / antagonists & inhibitors*
  • Cocaine / pharmacology
  • Conditioning, Operant / drug effects*
  • Isradipine
  • Male
  • Motor Activity / drug effects
  • Oxadiazoles / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Reinforcement, Psychology

Substances

  • Calcium Channel Blockers
  • Oxadiazoles
  • Cocaine
  • Isradipine