Gastrointestinal stromal tumour of the rectum: report of a case and review of literature

World J Gastroenterol. 2008 Feb 28;14(8):1302-4. doi: 10.3748/wjg.14.1302.

Abstract

Gastrointestinal stromal tumour (GIST) is a rare tumour of the gastrointestinal tract which does not generally originate in the rectum. The authors describe a case of a 70-year-old man who underwent an anterior resection of the rectum for a low-risk GIST. The patient was not given adjuvant chemotherapy with imatinib and is still disease-free 30 mo after surgery. The authors conclude that although rectal GIST is extremely uncommon, it should be included in differential diagnosis when a tumour in the rectum is detected. Biopsy of the tumour is essential, since this makes it possible to reach a sure preoperative diagnosis based on the immunohistological features of the CD117 and CD34. Although complete surgical resection with negative tumour margins is the principal curative procedure for primary and non-metastatic tumours, further studies are still needed for the determination of the most effective treatment strategy for patients with rectal GIST.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, CD34 / biosynthesis
  • Antineoplastic Agents / therapeutic use
  • Benzamides
  • Combined Modality Therapy / methods
  • Gastrointestinal Stromal Tumors / diagnosis
  • Gastrointestinal Stromal Tumors / therapy*
  • Humans
  • Imatinib Mesylate
  • Male
  • Piperazines / therapeutic use
  • Proto-Oncogene Proteins c-kit / biosynthesis
  • Pyrimidines / therapeutic use
  • Rectal Neoplasms / diagnosis
  • Rectal Neoplasms / therapy*
  • Treatment Outcome

Substances

  • Antigens, CD34
  • Antineoplastic Agents
  • Benzamides
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate
  • Proto-Oncogene Proteins c-kit