ABSTRACT The Centers for Disease Control and Prevention (CDC) is committed to achieving true improvements in people's health. In chronic disease prevention and health promotion, we have a good deal of evidence about which intervention strategies work in clinics and in communities to improve health, but we need to accelerate translating that evidence into practice. This paper provides an overview of initial efforts of the National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) within the CDC to identify and organize the fundamental elements of translation, with the goal of understanding what our constituents need for success and to identify key issues to consider in translation.