Abstract
We report here a fatal case of nosocomial pneumonia due to a multidrug-resistant (MDR) strain of Enterobacter cloacae, which was also resistant to carbapenems, in a patient with a diagnosis of Churg-Strauss syndrome. The microorganism was investigated for the presence of metallo- and extended-spectrum beta-lactamases. The strain produced two class 1 integrons carrying bla(VIM-1) and aadA2 gene cassettes located on chromosomal and plasmidic DNA, respectively, and a plasmid-encoded SHV-12 extended-spectrum beta-lactamase. Our results clearly demonstrate the transfer of this kind of resistance in E. cloacae with potentially serious clinical implications.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bacterial Proteins / genetics*
-
Churg-Strauss Syndrome / complications
-
Cross Infection / complications
-
Cross Infection / drug therapy
-
Cross Infection / microbiology
-
Drug Resistance, Multiple, Bacterial
-
Enterobacter cloacae / enzymology*
-
Enterobacteriaceae Infections / complications
-
Enterobacteriaceae Infections / drug therapy
-
Enterobacteriaceae Infections / microbiology*
-
Fatal Outcome
-
Humans
-
Integrons*
-
Male
-
Middle Aged
-
Pneumonia, Bacterial / complications
-
Pneumonia, Bacterial / drug therapy
-
Pneumonia, Bacterial / microbiology*
-
Polymerase Chain Reaction
-
beta-Lactam Resistance*
-
beta-Lactamases / genetics*
Substances
-
Bacterial Proteins
-
beta-Lactamases
-
carbapenemase