Abstract
Unmodified [60]fullerenes (C60) were solubilised with high stability using various type of poly(ethylene glycol) (PEG) based block copolymer micelles. Block copolymer micelle-incorporated C60 fullerenes were studied in cultures for biological activities using human cervical cancer HeLa cells. As a result, the cationic block copolymer micelles delivered C60 into the cells depending on their surface densities and showed cytotoxicity under photoirradiation.
MeSH terms
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Apoptosis / drug effects
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Cations
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Female
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Fullerenes / chemistry*
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Fullerenes / pharmacology
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HeLa Cells
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Humans
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Light
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Micelles*
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Molecular Structure
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / pharmacology
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Polyethylene Glycols / chemistry*
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Polymers / chemical synthesis
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Polymers / chemistry*
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Polymers / pharmacokinetics
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Solubility
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Uterine Cervical Neoplasms / drug therapy*
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Uterine Cervical Neoplasms / metabolism
Substances
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Cations
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Fullerenes
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Micelles
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Photosensitizing Agents
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Polymers
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Polyethylene Glycols
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fullerene C60