Motor learning transiently changes cortical somatotopy

Neuroimage. 2008 May 1;40(4):1748-54. doi: 10.1016/j.neuroimage.2007.11.018. Epub 2007 Nov 28.

Abstract

Learning a complex motor skill is associated with changes in motor cortex representations of trained body parts. It has been suggested that representation changes reflect the storage of a skill, i.e., the motor memory trace. If a reflection of the trace, such modifications should persist after training is stopped for as long as the skill is retained. The objective here was to test the persistence of learning-related changes in the representation of the forelimb of the rat after learning a reaching task using repeated epidural stimulation mapping of primary motor cortex. It is shown that the forelimb representations enlarge after 8 days of training (n=8) but contract while performing arm movements without learning (n=7, p=0.006); hindlimb representations remain unchanged. Enlargement correlated with learning success (r=0.82; p=0.012). Subsequently, after 8 days without training, representation size reverted to baseline while the motor skill was retained. Somatotopy remained unaltered by a second training phase in which performance did not improve further (n=5). These findings suggest that successful acquisition but not storage of a motor skill depends on cortical map changes. The motor memory trace in rats may require changes in motor cortex organization other than those detected by stimulation mapping.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Mapping
  • Cerebral Cortex / physiology*
  • Data Interpretation, Statistical
  • Epidural Space / physiology
  • Forelimb / blood supply
  • Forelimb / innervation
  • Learning / physiology*
  • Linear Models
  • Motor Cortex / physiology
  • Motor Skills / physiology*
  • Psychomotor Performance / physiology
  • Rats
  • Rats, Long-Evans
  • Regional Blood Flow / physiology