Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity

Robert Musiol; Dominik Tabak; Halina Niedbala; Barbara Podeszwa; Josef Jampilek; Katarina Kralova; Jiri Dohnal; Jacek Finster; Agnieszka Mencel; Jaroslaw Polanski

doi:10.1016/j.bmc.2008.02.065

Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity

Bioorg Med Chem. 2008 Apr 15;16(8):4490-9. doi: 10.1016/j.bmc.2008.02.065. Epub 2008 Feb 23.

Authors

Robert Musiol¹, Dominik Tabak, Halina Niedbala, Barbara Podeszwa, Josef Jampilek, Katarina Kralova, Jiri Dohnal, Jacek Finster, Agnieszka Mencel, Jaroslaw Polanski

Affiliation

¹ Institute of Chemistry, University of Silesia, Szkolna 9, 40006 Katowice, Poland.

PMID: 18342517
DOI: 10.1016/j.bmc.2008.02.065

Abstract

Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard (DCMU). The structure-activity relationships are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Chlorella vulgaris / drug effects
Chlorella vulgaris / metabolism
Chlorophyll / metabolism
Chloroplasts / drug effects
Hydrophobic and Hydrophilic Interactions
Hydroxyquinolines / chemical synthesis*
Hydroxyquinolines / chemistry
Hydroxyquinolines / pharmacology*
Lipids / chemistry
Molecular Structure
Photosynthesis
Spinacia oleracea / drug effects
Structure-Activity Relationship

Substances

Amides
Hydroxyquinolines
Lipids
Chlorophyll